An exceptional case of streptococcal toxic shock syndrome

doi:N/A

eISSN: None / ISSN: None

Netharland Journal of Critical Care

2011, Volume 15, Issue 1 : 27-29

Article

An exceptional case of streptococcal toxic shock syndrome

van der Oord B.M.

Hol C.

Manten B.

Abstract

Streptococcal Toxic Shock Syndrome (TSS) is caused by an infection with Group A Streptococcus (GAS). Streptococcal pyrogenic exotoxins type A (SPEA) and/or type B (SPEB) are found in the majority of cases of severe GAS infections and play an important role in virulence. These exotoxins can activate the immune system by bypassing the usual antigen-mediated immune response sequence, resulting in the release of large quantities of inflammatory cytokines. These cytokines cause capillary leak and tissue damage, leading to shock and Multi Organ Failure. Overall mortality is 30 to 80 percent, despite aggressive modern therapy [1,2,3,4]. Even though early symptoms can be vague and unspecific, as in our case, it is important to suspect and diagnose TSS at an early stage, because early treatment may have a beneficial effect on outcome. © 2011, Nederlandse Vereniging voor Intensive Care. All Rights Reserved.

Keywords

Immunoglobulin-therapy

Streptococcal toxic shock syndrom

TSS

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