Antisynthetase syndrome, a rare cause of respiratory failure

doi:N/A

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Netharland Journal of Critical Care

2023, Volume 33, Issue 1 : 5-8

Article

Antisynthetase syndrome, a rare cause of respiratory failure

Mulder T.

Huijsmans R.L.N.

de Klerk B.

Kamphuis J.S.

Spronk P.E.

Abstract

A 72-year-old patient was admitted to the intensive care unit with respiratory failure due to rapidly progressive interstitial lung disease (ILD). All cultures and PCRs focused on ILD were negative and a paraneoplastic phenomenon was deemed unlikely after screening for malignancy. Inflammatory myositis was suspected as the patient also presented fever, progressive pitting oedema and arthritis in both hands and feet. A myositis blot revealed high titres of anti-Jo-1 antibodies: the patient was diagnosed with antisynthetase syndrome and was treated with high-dose corticosteroids, cyclophosphamide and intravenous immunoglobulins with a gradual full recovery. Antisynthetase syndrome should be considered in patients with idiopathic or rapidly progressive ILD. © 2023, Netherlands Society of Intensive Care. All rights reserved.

Keywords

Antisynthetase syndrome

Myositis

Respiratory failure

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