Cardioprotective and anti-inflammatory effects of glutamine in parenteral nutrition

doi:N/A

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Netharland Journal of Critical Care

2017, Volume 25, Issue 1 : 6-8

Review

Cardioprotective and anti-inflammatory effects of glutamine in parenteral nutrition

Leguina-Ruzzi A.

Biochemistry Department, Research Institute for Disease of Old Age, Juntendo University, Tokyo, Japan

Abstract

Glutamine is the most abundant free amino acid with multiple biological functions. The supplementation of this amino acid to parenteral nutrition has been widely used for the management of ICU complications. However, inconclusive reports have generated reluctance in the use of this pharmaco-nutrient. In the last decade, new studies have reported the beneficial effects for the cardiovascular and pulmonary system, besides its classical functions as antioxidant, immunomodulator and substrate for other molecules. From the medical science point of view, considering clinical and in vivo studies, the evidence describes several metabolic pathways in which glutamine plays a beneficial role. These pleiotropic effects support the participation of glutamine as a cardioprotective and antiinflammatory amino acid. © 2017, Netherlands Society of Intensive Care. All rights reserved.

Keywords

Anti-inflammatory

Cardioprotective

Glutamine

Molecular targets

Parenteral nutrition

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