Euglycaemic diabetic ketoacidosis as a severe complication of dapagliflozin

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eISSN: None / ISSN: None

Netharland Journal of Critical Care

2022, Volume 30, Issue 2 : 71-73

Article

Euglycaemic diabetic ketoacidosis as a severe complication of dapagliflozin

Hogenkamp C.G.J.B.

Veneman S.K.

Backus E.M.J.M.

Veneman T.F.

Abstract

Diabetic ketoacidosis (DKA) is a severe and potentially lethal complication of diabetes. The use of a relatively new class of antihyperglycaemic drugs, the SGLT2 inhibitors, can cause DKA, albeit with a different presentation compared to the ‘classic’ DKA. Therefore, since it might not be recognised at an early stage, awareness of this specific presentation of DKA as a complication of the use of SGLT2 inhibitors is important. In addition, the risk of dapagliflozin-induced DKA can be reduced by timely precautions, in particular around surgery or during fasting. We describe a case of dapagliflozin-associated DKA, and explain its underlying potential mechanisms. © 2022, Netherlands Society of Intensive Care. All rights reserved.

Keywords

Dapagliflozin

Diabetic ketoacidosis

Euglycemia

SGLT2-inhibitors

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