Intestinal barrier loss in sepsis

doi:N/A

eISSN: None / ISSN: None

Netharland Journal of Critical Care

2011, Volume 15, Issue 4 : 199-203

Review

Intestinal barrier loss in sepsis

Thuijls G.

Derikx J.P.M.

Grootjans J.

Buurman W.A.

van Waardenburg D.A.

Abstract

The intestinal mucosa is responsible for the absorption of nutrients from the lumen. In addition, it has the challenging task to provide an effective barrier between the potentially toxic luminal content (external environment) and the host (internal environment). Intestinal barrier loss plays a key role in the development and perpetuation of a variety of intestinal disease states. It is involved in the onset of sepsis and multiple organ failure and can be caused by intestinal hypoperfusion. This review will focus on the current insights into gut barrier integrity and function loss, which is important in order to improve our knowledge on disease aetiology and may contribute to early detection or prevention of sepsis. Copyright © 2011, Nederlandse Vereniging voor Intensive Care.

Keywords

I-FABP

Intestinal barrier loss

Sepsis

Splanchnic hypoperfusion

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