Necrotising laryngitis and epiglottitis in a patient with methimazole-induced agranulocytosis

doi:N/A

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Netharland Journal of Critical Care

2015, Volume 22, Issue 4 : 18-20

Article

Necrotising laryngitis and epiglottitis in a patient with methimazole-induced agranulocytosis

Popal S.

Verbaan B.W.

Vreeburg G.C.M.

Ramakers B.P.

Abstract

Antithyroid drug-induced neutropenia is a rare and potentially life-threatening complication with an incidence of agranulocytosis ranging from 1-5 cases per million per year. Here we report a case of a 57-year-old female with septic shock due to necrotising laryngitis and epiglottitis as a result of methimazole-induced agranulocytosis. She was treated with antibiotics, granulocyte colony-stimulating factor, and radiological and surgical abscess drainage during a 24-day stay in the ICU. This case underlines once more the importance of patient education with the use of antithyroid drugs. © 2015, Netherlands Society of Intensive Care. All rights reserved.

Keywords

Agranulocytosis

Antithyroid drug

Epiglottitis

Laryngitis

Methimazole

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