Tight glucose control in the post-NICE SUGAR era

doi:N/A

eISSN: None / ISSN: None

Netharland Journal of Critical Care

2009, Volume 13, Issue 3 : 126-127

Editorial

Tight glucose control in the post-NICE SUGAR era

Preiser J.-C.

Department of Intensive Care, Centre Hospitalier Universitaire du Sart Tilman, Liege, Belgium

Abstract

The results of the NICE SUGAR (Normoglycaemia in Intensive Care Evaluation Survival Using Glucose Algorithm Regulation) trial were released last March. The primary outcome variable of the study, 90-day mortality, was found increased in patients randomised to intensive insulin therapy, as compared with insulin therapy that targeted an intermediate range for blood glucose. These findings reported from data collected in a set of more than 6,000 patients invalidate the external validity of tight glucose control and attenuates the wave of enthusiasm that followed the release of the Leuven I study in 2001. Future research will be needed to address the numerous questions raised by the divergent results reported from investigations in the field of glucose control in the critically ill. Copyright © 2009, Nederlandse Vereniging voor Intensive Care. All rights reserved.

Keywords

Carbohydrate metabolism

Hypoglycaemia

Intensive insulin therapy

Stress hyperglycaemia

Stress metabolism

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