Tricyclic antidepressant poisoning: Cardiovascular and neurological toxicity

doi:N/A

eISSN: None / ISSN: None

Netharland Journal of Critical Care

2016, Volume 24, Issue 2 : 1-19

Article

Tricyclic antidepressant poisoning: Cardiovascular and neurological toxicity

Verbree F.C.

Reijnen T.M.A.J.

Mitrov-Winkelmolen L.

Overdiek J.W.P.M.

⁴

Dennesen P.J.W.

⁵

Department of Emergency medicine, St Antonius Hospital, Nieuwegein, Netherlands

Department of Emergency Medicine, Medical Center Haaglanden, The Hague, Netherlands

Department of Pharmacology, The Hague hospital pharmacy, The Hague, Netherlands

⁴

Critical Care, Medical Center Haaglanden, The Hague, Netherlands

⁵

Department of Clinical Pharmacy, Ikazia Hospital and Maasstad Hospital, Rotterdam, Netherlands

Abstract

Tricyclic antidepressant poisoning is a potentially lethal condition and treatment can be challenging. ECG findings are the most important risk stratification and should be used to guide subsequent therapy. Sodium bicarbonate is the main treatment along with activated charcoal. When high doses of a tricyclic antidepressant are ingested, the anticholinergic effect may be substantial. © 2016, Netherlands Society of Intensive Care. All rights reserved.

Keywords

Intoxication

Nortriptyline

Overdose

Tricyclic antidepressants

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